Microbiology / Biophysics Postdoc Fellow or Researcher Position

We are seeking a microbiology / biophysics Researcher at PhD, MS or equivalent levels for participating in the chemical genomics drug discovery projects (http://www.cbligand.org/CCGS/ ).  The candidate must have expertise and working experience in the purification and characterization of proteins in E. coli and baculovirus systems using LC and MS analytical and proteomic techniques.  Experience with X-ray protein crystallization studies is plus.  Must demonstrated ability to design, execute and analyze experiments under supervision.  Good written, verbal, and interpersonal skills are needed. Salary will be commensurate with experience. Please email your CV and three references to: Prof. XQ (Sean) Xie, Dept. of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261. Terry McGuire tfm1@pitt.edu and cc to xix15@pitt.edu

Computational Biology/Genomics/Chemogenomics or Pharmacometrics

The University of Pittsburgh School of Pharmacy is seeking the following candidates in the Department of Pharmaceutical Sciences.  The successful applicant will be a member of the Computational Chemical Genomics Screening (CCGS) Center (www.CBLigand.org/CCGS), and will closely interact with the NIH funded Center of Excellence for Computational Drug Abuse Research (www.CDAR.org).  The Centers are developing and implementing state-of-the-art computational chemical genomics technologies. The Centers are also centralizing the “Big Data” disease domain specific chemogenomics and computational programs/tools through a GPU-accelerated cloud computing server platform in order to enable efficient information exchange and to advance drug target identification and system polypharmacology.  The goal is to accelerate the development of novel therapeutic intervention strategies for drug discovery, design and development.

Postdoc Fellow or Researcher Position Available . We are seeking a creative, self-motivated individual (Postdoc fellow or Programmer) with excellent interpersonal, writing and problem solving skills who is interested in working in a dynamic drug discovery environment. The successful candidate will be responsible for computational, big-data type projects and network algorithm development. Applicant must have strong background in programming, program testing and deployment, and have experience in large data modeling/analysis, database administration, and graphical user interface (GUI) design. Proficiency in at least one object-oriented programming language (e.g., Java, C++ or C#), and scripting language (e.g., Python, PHP) is preferred. Experience with GPU programming and computing, web/mobile application development, big data analysis, network information security, and Web services methodologies are desired. It is also desirable to have experience in developing modeling techniques for similarity searching and docking, in silico ADMET and off-target modeling as well as broad experience in small molecule drug discovery. The applicant must have a PhD or MS degree or equivalent, and strong communication and writing skills.

Review of applications will begin immediately and will continue until the position is filled. Applicants should send a letter describing their interest in the position, a description of their current and/or future research interests, a complete curriculum vitae and the names of at least four individuals who will serve as references to: *Dr. Xiang-Qun (Sean) Xie, Associate Dean and Director of CCGS and CDAR Centers, Xix15@Pitt.edu and his assistant Dr. T McGuire tfml@pitt.edu

Assistant Professor/Assistant Research Professor (Aug. 28, 2015)

Assistant Professor
Computational Chemical Genomics Screening Center
Department of Pharmaceutical Sciences
School of Pharmacy
University of Pittsburgh

We are seeking candidates for a position at the rank of assistant professor (non-tenure stream) with a background in pharmacology, biochemistry or biophysics. The successful candidate will be expected to oversee and mentor postdoctoral researchers and graduate students working on chemical biology projects in the NIH funded Computational Chemical Genomics Screening Center (http://www.cbligand.org/xielab). The candidate’s research should be focused on drug development related to osteoporosis, neurological diseases, cancer or hematopoietic stem cells, preferably by targeting GPCRs, cannabinoid CB2 receptor, p18 or p62. Candidates should have a PhD, MD, PharmD or equivalent, and have strong communication and writing skills.

Applicants should send a letter describing their interest in the position, a description of their current and/or future research interests, a complete curriculum vitae and the names of at least four individuals who will serve as references to: Professor Sean Xie, Director of Computational Chemical Genomics Screening Center (www.CBLigand.org/CCGS), University of Pittsburgh, Pittsburgh, PA 15261.   xix15@pitt.edu (Sean Xie), and Terence McGuire (tfm1@pitt.edu). The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer.