PAINS (pan assay interference compounds) is likely to interfere in screening technologies via a number of means but particularly through protein reactivity. They represent poor choices for drug development and yet can furnish data that in isolation may be suggestive of a selective and optimizable hit. PAINS-Remover is designed and constructed to remove the Pan Assay Interference Compounds (PAINS) from screening libraries and for their exclusion in bioassays. This server will facility data-sharing and information exchange among UPCMLD scientific research communities with online structure search functions and data analysis tools implemented for removal of PAINS compounds.
PAINS-Remover was created and maintained by Prof. Xiang-Qun (Sean) Xie’s laboratory
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(Last updated on Nov, 2010)