Protein Targets

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Protein Protein name Organism Symbol Gene UniProt ChEMBL Compounds
5-hydroxytryptamine receptor 1B Homo sapiens; Human 5HT1B_HUMAN HTR1B P28222 CHEMBL1898 2475 / 2634
5-hydroxytryptamine receptor 2A Homo sapiens; Human 5HT2A_HUMAN HTR2A P28223 CHEMBL224 8589 / 10505
5-hydroxytryptamine receptor 2B Homo sapiens; Human 5HT2B_HUMAN HTR2B P41595 CHEMBL1833 4230 / 5981
5-hydroxytryptamine receptor 2C Homo sapiens; Human 5HT2C_HUMAN HTR2C P28335 CHEMBL225 7347 / 9196
adenosine A1 receptor Homo sapiens; Human AA1R_HUMAN ADORA1 P30542 CHEMBL226 12364 / 14663
adenosine A2a receptor Homo sapiens; Human AA2AR_HUMAN ADORA2A P29274 CHEMBL251 11667 / 13796
acetylcholinesterase (Cartwright blood group) Homo sapiens; Human ACES_HUMAN ACHE P22303 CHEMBL220 11910 / 14414
angiotensin I converting enzyme Homo sapiens; Human ACE_HUMAN ACE P12821 CHEMBL1808 1303 / 1342
cholinergic receptor nicotinic alpha 9 subunit Homo sapiens; Human ACHA9_HUMAN CHRNA9 Q9UGM1 CHEMBL2184 1 / 1
cholinergic receptor nicotinic beta 2 subunit Homo sapiens; Human ACHB2_HUMAN CHRNB2 P17787 CHEMBL1883 1 / 1
cholinergic receptor muscarinic 1 Homo sapiens; Human ACM1_HUMAN CHRM1 P11229 CHEMBL216 6980 / 8900
cholinergic receptor muscarinic 4 Homo sapiens; Human ACM4_HUMAN CHRM4 P08173 CHEMBL1821 3558 / 5422
adrenoceptor beta 2 Homo sapiens; Human ADRB2_HUMAN ADRB2 P07550 CHEMBL210 6371 / 8365
angiotensin II receptor type 2 Homo sapiens; Human AGTR2_HUMAN AGTR2 P50052 CHEMBL4607 651 / 2421
aldo-keto reductase family 1 member B Homo sapiens; Human ALDR_HUMAN AKR1B1 P15121 CHEMBL1900 1321 / 1331
alanyl aminopeptidase, membrane Homo sapiens; Human AMPN_HUMAN ANPEP P15144 CHEMBL1907 758 / 825
monoamine oxidase A Homo sapiens; Human AOFA_HUMAN MAOA P21397 CHEMBL1951 6430 / 8557
monoamine oxidase B Homo sapiens; Human AOFB_HUMAN MAOB P27338 CHEMBL2039 7134 / 7397
beta-secretase 1 Homo sapiens; Human BACE1_HUMAN BACE1 P56817 CHEMBL4822 14729 / 14951
carbonic anhydrase 2 Homo sapiens; Human CAH2_HUMAN CA2 P00918 CHEMBL205 14049 / 15886
caspase 1 Homo sapiens; Human CASP1_HUMAN CASP1 P29466 CHEMBL4801 4358 / 6156
cyclin dependent kinase 5 Homo sapiens; Human CDK5_HUMAN CDK5 Q00535 CHEMBL4036 2849 / 2934
butyrylcholinesterase Homo sapiens; Human CHLE_HUMAN BCHE P06276 CHEMBL1914 5165 / 5449
cannabinoid receptor 1 Homo sapiens; Human CNR1_HUMAN CNR1 P21554 CHEMBL218 14060 / 16708
cannabinoid receptor 2 Homo sapiens; Human CNR2_HUMAN CNR2 P34972 CHEMBL253 14804 / 15481
proopiomelanocortin Homo sapiens; Human COLI_HUMAN POMC P01189
catechol-O-methyltransferase Homo sapiens; Human COMT_HUMAN COMT P21964 CHEMBL2023 341 / 345
C-reactive protein Homo sapiens; Human CRP_HUMAN CRP P02741
C-X-C motif chemokine receptor 1 Homo sapiens; Human CXCR1_HUMAN CXCR1 P25024 CHEMBL4029 459 / 2217
C-X-C motif chemokine receptor 4 Homo sapiens; Human CXCR4_HUMAN CXCR4 P61073 CHEMBL2107 2874 / 3025
dopamine receptor D2 Homo sapiens; Human DRD2_HUMAN DRD2 P14416 CHEMBL217 17907 / 20602
dopamine receptor D3 Homo sapiens; Human DRD3_HUMAN DRD3 P35462 CHEMBL234 9435 / 11350
dopamine receptor D4 Homo sapiens; Human DRD4_HUMAN DRD4 P21917 CHEMBL219 4850 / 6919
endothelin 1 Homo sapiens; Human EDN1_HUMAN EDN1 P05305
estrogen receptor 1 Homo sapiens; Human ESR1_HUMAN ESR1 P03372 CHEMBL206 11495 / 13661
fatty acid binding protein 5 Homo sapiens; Human FABP5_HUMAN FABP5 Q01469 CHEMBL3674 227 / 228
FYN proto-oncogene, Src family tyrosine kinase Homo sapiens; Human FYN_HUMAN FYN P06241 CHEMBL1841 3379 / 5142
glycine receptor alpha 3 Homo sapiens; Human GLRA3_HUMAN GLRA3 O75311 CHEMBL1075092 28 / 44
glycine receptor alpha 3 Homo sapiens; Human GLRA3_HUMAN GLRA3 O75311 CHEMBL1075092 28 / 44
glutamate metabotropic receptor 5 Homo sapiens; Human GRM5_HUMAN GRM5 P41594 CHEMBL3227 5553 / 5718
hematopoietic prostaglandin D synthase Homo sapiens; Human HPGDS_HUMAN HPGDS O60760 CHEMBL5879 428 / 443
histamine receptor H1 Homo sapiens; Human HRH1_HUMAN HRH1 P35367 CHEMBL231 3452 / 5410
epoxide hydrolase 2 Homo sapiens; Human HYES_HUMAN EPHX2 P34913 CHEMBL2409 2943 / 3078
inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens; Human IKKB_HUMAN IKBKB O14920 CHEMBL1991 5308 / 5424
ATP binding cassette subfamily B member 1 Homo sapiens; Human MDR1_HUMAN ABCB1 P08183 CHEMBL4302 12046 / 12471
macrophage migration inhibitory factor Homo sapiens; Human MIF_HUMAN MIF P14174 CHEMBL2085 712 / 779
mitogen-activated protein kinase 1 Homo sapiens; Human MK01_HUMAN MAPK1 P28482 CHEMBL4040 21420 / 23200
mitogen-activated protein kinase 3 Homo sapiens; Human MK03_HUMAN MAPK3 P27361 CHEMBL3385 2850 / 4619
mechanistic target of rapamycin kinase Homo sapiens; Human MTOR_HUMAN MTOR P42345 CHEMBL2842 12931 / 13105
membrane metalloendopeptidase Homo sapiens; Human NEP_HUMAN MME P08473 CHEMBL1944 768 / 803
tachykinin receptor 1 Homo sapiens; Human NK1R_HUMAN TACR1 P25103 CHEMBL249 4191 / 5999
glutamate ionotropic receptor NMDA type subunit 2A Homo sapiens; Human NMDE1_HUMAN GRIN2A Q12879 CHEMBL1972 64 / 64
glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens; Human NMDE2_HUMAN GRIN2B Q13224 CHEMBL1904 378 / 388
glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens; Human NMDZ1_HUMAN GRIN1 Q05586 CHEMBL2015 120 / 120
nitric oxide synthase 1 Homo sapiens; Human NOS1_HUMAN NOS1 P29475 CHEMBL3568 1652 / 1709
nitric oxide synthase 2 Homo sapiens; Human NOS2_HUMAN NOS2 P35228 CHEMBL4481 1518 / 1561
neurotrophic receptor tyrosine kinase 1 Homo sapiens; Human NTRK1_HUMAN NTRK1 P04629 CHEMBL2815 6670 / 6744
opioid receptor delta 1 Homo sapiens; Human OPRD_HUMAN OPRD1 P41143 CHEMBL236 10731 / 12871
opioid receptor kappa 1 Homo sapiens; Human OPRK_HUMAN OPRK1 P41145 CHEMBL237 11463 / 13975
Mu-type opioid receptor Mus musculus; Mouse OPRM_MOUSE OPRM1 P42866 CHEMBL2858 1273 / 1305
opioid related nociceptin receptor 1 Homo sapiens; Human OPRX_HUMAN OPRL1 P41146 CHEMBL2014 3236 / 3473
purinergic receptor P2X 3 Homo sapiens; Human P2RX3_HUMAN P2RX3 P56373 CHEMBL2998 1753 / 1766
purinergic receptor P2Y12 Homo sapiens; Human P2Y12_HUMAN P2RY12 Q9H244 CHEMBL2001 2182 / 2252
coagulation factor II thrombin receptor Homo sapiens; Human PAR1_HUMAN F2R P25116 CHEMBL3974 1685 / 1744
phosphodiesterase 4B Homo sapiens; Human PDE4B_HUMAN PDE4B Q07343 CHEMBL275 2179 / 2250
phosphodiesterase 5A Homo sapiens; Human PDE5A_HUMAN PDE5A O76074 CHEMBL1827 2951 / 4759
myeloperoxidase Homo sapiens; Human PERM_HUMAN MPO P05164 CHEMBL2439 762 / 857
Prostaglandin G/H synthase 1 Ovis aries; Sheep PGH1_SHEEP PTGS1 P05979 CHEMBL2949 4535 / 4757
prostaglandin-endoperoxide synthase 2 Homo sapiens; Human PGH2_HUMAN PTGS2 P35354 CHEMBL230 9578 / 11566
acid phosphatase 3 Homo sapiens; Human PPAP_HUMAN ACP3 P15309 CHEMBL2633 69 / 69
peroxisome proliferator activated receptor gamma Homo sapiens; Human PPARG_HUMAN PPARG P37231 CHEMBL235 12255 / 12983
progesterone receptor Homo sapiens; Human PRGR_HUMAN PGR P06401 CHEMBL208 5093 / 5407
prostaglandin E synthase Homo sapiens; Human PTGES_HUMAN PTGES O14684 CHEMBL5658 2864 / 3011
solute carrier family 6 member 4 Homo sapiens; Human SC6A4_HUMAN SLC6A4 P31645 CHEMBL228 8233 / 10152
sodium voltage-gated channel alpha subunit 9 Homo sapiens; Human SCN9A_HUMAN SCN9A Q15858 CHEMBL4296 8109 / 8154
toll like receptor 4 Homo sapiens; Human TLR4_HUMAN TLR4 O00206 CHEMBL5255 770 / 848
tumor necrosis factor Homo sapiens; Human TNFA_HUMAN TNF P01375 CHEMBL1825 1611 / 1704
thrombomodulin Homo sapiens; Human TRBM_HUMAN THBD P07204
transient receptor potential cation channel subfamily M member 4 Homo sapiens; Human TRPM4_HUMAN TRPM4 Q8TD43 CHEMBL1628469 16 / 16
Uncharacterized protein Ficedula albicollis; Collared flycatcher; Muscicapa albicollis TRPM8_FICAL TRPM8 U3JD03
Transient receptor potential cation channel subfamily V member 1 Rattus norvegicus; Rat TRPV1_RAT TRPV1 O35433 CHEMBL5102 2882 / 3263
Transient receptor potential cation channel subfamily V member 2 Oryctolagus cuniculus; Rabbit TRPV2_RABIT TRPV2 G1SNM3
transient receptor potential cation channel subfamily V member 3 Homo sapiens; Human TRPV3_HUMAN TRPV3 Q8NET8 CHEMBL5522 520 / 520
thioredoxin reductase 1 Homo sapiens; Human TRXR1_HUMAN TXNRD1 Q16881 CHEMBL1927 51 / 71
serine protease 1 Homo sapiens; Human TRY1_HUMAN PRSS1 P07477 CHEMBL209 2186 / 2302