Protein Targets

Protein Protein name Organism Symbol Gene UniProt ChEMBL Compounds
Genome polyprotein Human enterovirus 71; EV71; EV-71 2A_HE71 2A A9XG43
Genome polyprotein Human enterovirus 71; strain 7423/MS/87; EV71; EV-71 2A_HE71M 2A Q66479
Genome polyprotein Human enterovirus 71; EV71; EV-71 2C_HE71 2C B9VUU3
Genome polyprotein Enterovirus F 3A_9ENTO 3A Q2LKY9
Genome polyprotein Human enterovirus 71; strain 7423/MS/87; EV71; EV-71 3A_HE71M 3A Q66479
Genome polyprotein Human enterovirus D68; EV68; EV-68 3A_HED68 3A A0A2K9Y515
Genome polyprotein Human enterovirus 71; EV71; EV-71 3C_HE71 3C B8YLV9
Genome polyprotein Human enterovirus D68; EV68; EV-68 3C_HED68 3C A1E4A3
Genome polyprotein Human enterovirus 71; EV71; EV-71 3D_HE71 3D I3UIB4
Genome polyprotein Human enterovirus D68; EV68; EV-68 3D_HED68 3D F1T146
angiotensin converting enzyme 2 Homo sapiens; Human ACE2_HUMAN ACE2 Q9BYF1 CHEMBL3736 107 / 107
Capsid protein Feline calicivirus CAPSD_9CALI CAPSD A2T4Q0
Genome polyprotein Enterovirus F CAPSD_9ENTO CAPSD Q2LKZ0
Genome polyprotein Dengue virus type 2; strain Puerto Rico/PR159-S1/1969; DENV-2 CAPSD_DEN2P CAPSD P12823 CHEMBL3308998 78 / 78
Genome polyprotein Hepatitis C virus genotype 1a; isolate H77; HCV CAPSD_HCV77 CAPSD P27958 CHEMBL3638344 903 / 903
Capsid protein VP0 Human enterovirus D68; EV68; EV-68 CAPSD_HED68 VP1 Q9YLJ3
Core protein Zika virus; ZIKV CAPSD_ZIKV CAPSD A0A0X8GJ44
DNA polymerase catalytic subunit Human herpesvirus 1; strain KOS; HHV-1; Human herpes simplex virus 1 DPM_HHV1K UL30 P04292 CHEMBL5944 4 / 5
Envelope glycoprotein E1 Hepacivirus C E1_9HEPC E1 H9XGD6
Genome polyprotein Hepatitis C virus genotype 1a; isolate H77; HCV E1_HCV77 E1 P27958 CHEMBL3638344 903 / 903
Genome polyprotein Hepatitis C virus genotype 1b; isolate HC-J1; HCV E1_HCVJ1 E1 Q03463
Core protein precursor Hepacivirus C E2_9HEPC E2 C1KH25
Genome polyprotein Hepatitis C virus genotype 1a; isolate H77; HCV E2_HCV77 E2 P27958 CHEMBL3638344 903 / 903
Envelope protein E Dengue virus 1 ENV_9FLAV E Q8BE39
Genome polyprotein Dengue virus type 1; strain Brazil/97-11/1997; DENV-1 ENV_DEN1B ENV P27909
Genome polyprotein Dengue virus type 2; strain Puerto Rico/PR159-S1/1969; DENV-2 ENV_DEN2P ENV P12823 CHEMBL3308998 78 / 78
Genome polyprotein Dengue virus type 3; strain Philippines/H87/1956; DENV-3 ENV_DEN3P ENV P27915
Envelope glycoprotein H Human herpesvirus 2; strain HG52; HHV-2; Human herpes simplex virus 2 ENV_HHV2H GH P89445
Core protein Zika virus; ZIKV ENV_ZIKV ENV A0A0X8GJ44
Genome polyprotein Zika virus; isolate ZIKV/Human/French Polynesia/10087PF/2013; ZIKV ENV_ZIKVK ENV A0A024B7W1
Envelope polyprotein Andes orthohantavirus G1_ADNV G1 Q99BV0
Envelope polyprotein Andes orthohantavirus G2_ADNV M Q9E006
Envelope glycoprotein B Human herpesvirus 1; strain 17; HHV-1; Human herpes simplex virus 1 GB_HHV11 GB P10211 CHEMBL2364696
Envelope glycoprotein B Human herpesvirus 1; strain KOS; HHV-1; Human herpes simplex virus 1 GB_HHV1K GB P06437
Glycoprotein D Suid alphaherpesvirus 1 GD_9ALPH US6 G3G933
Glycoprotein D Human herpesvirus 1; HHV-1; Human herpes simplex virus 1 GD_HHV1 GD Q991M3
Envelope glycoprotein gp160 Human immunodeficiency virus 1 GP160_HIV1 ENV C6G099
Envelope glycoprotein gp160 Human immunodeficiency virus type 2 subtype A; isolate ST; HIV-2 GP160_HIV2 ENV P20872
Envelope glycoprotein Zaire ebolavirus; strain Mayinga-76; ZEBOV; Zaire Ebola virus GP_EBOV GP Q05320 CHEMBL4105829 32 / 32
Pre-glycoprotein polyprotein GP complex Lassa virus; strain Mouse/Sierra Leone/Josiah/1976; LASV GP_LASSJ GPC P08669
Hemagglutinin Influenza A virus; strain A/Chicken/Germany/n/1949 H10N7 HA_A-H10N7 HA P12581
Hemagglutinin Influenza A virus; A/Jiangxi/IPB13/2013; H10N8 HA_A-H10N8 HA A0A059T4A1
Hemagglutinin Influenza A virus; strain A/Gull/Maryland/704/1977 H13N6 HA_A-H13N6 HA P13103
Hemagglutinin Influenza A virus; strain A/Mallard/Astrakhan/244/1982 H14N6; Influenza A virus; strain A/Mallard/Gurjev/244/1982 H14N6 HA_A-H14N6 HA P26137
Hemagglutinin Influenza A virus; A/shearWater/Australia/2576/1979; H15N9 HA_A-H15N9 HA L0L3X3
Hemagglutinin Influenza A virus; A/little yellow-shouldered bat/Guatemala/060/2010; H17N10 HA_A-H17N10 HA H6QM93
Hemagglutinin HA_A-H18N11 HA
Hemagglutinin Influenza A virus; A/WDK/JX/12416/2005; H1N1 HA_A-H1N1 HA C7C6F1
Hemagglutinin Influenza A virus; strain A/Japan/305/1957 H2N2 HA_A-H2N2 HA P03451
Hemagglutinin Influenza A virus HA_A-H3N2 HA K7N5L2 CHEMBL2366448 2 / 2
Hemagglutinin Influenza A virus; A/eq/Newmarket/93/; H3N8 HA_A-H3N8 HAI Q82847
Hemagglutinin Influenza A virus; A/Vietnam/1194/2004; H5N1 HA_A-H5N1 HA Q6DQ34
Hemagglutinin Influenza A virus; strain A/Duck/Singapore/3/1997 H5N3; Influenza A virus; strain A/Duck/Malaysia/F119-3/1997 H5N3 HA_A-H5N3 HA A5Z226
Hemagglutinin H6N1 subtype HA_A-H6N1 HA A0A0J9X268
Hemagglutinin Influenza A virus; A/chicken/Guangdong/S1414/2010; H6N6 HA_A-H6N6 HA A0A067YZ73
Hemagglutinin Influenza A virus; A/chicken/New Jersey/Sg-00421/2004; H7N2 HA_A-H7N2 HA B7NY59
Hemagglutinin Influenza A virus; A/Netherlands/219/2003; H7N7 HA_A-H7N7 HA Q6VMK1
Hemagglutinin Influenza A virus; A/Hangzhou/1/2013; H7N9 HA_A-H7N9 HA M4YV75
Hemagglutinin Influenza B virus; strain B/Hong Kong/8/1973 HA_INFB HA P03462
Hemagglutinin-esterase-fusion glycoprotein Influenza D virus; D/swine/Oklahoma/1334/2011 HA_INFD HEF K9LG83
Hemagglutinin-esterase Bovine coronavirus; strain Mebus; BCoV; BCV HE_BCV HE P15776
Hemagglutinin-esterase Human coronavirus OC43; HCoV-OC43 HE_HCoV-OC43 HE Q4VID6
Hemagglutinin-esterase Murine coronavirus; strain DVIM; MHV-DVIM; Murine hepatitis virus HE_MHV HE O92367
Gag-Pol polyprotein Human immunodeficiency virus type 1 group M subtype B; isolate NY5; HIV-1 IN_HIV1 GAG-POL P12497
Replicase polyprotein 1ab Bat coronavirus HKU4; BtCoV; BtCoV/HKU4/2004 MD_HKU4 REP P0C6W3
Replicase polyprotein 1a Middle East respiratory syndrome-related coronavirus; isolate United Kingdom/H123990006/2012; MERS-CoV; Betacoronavirus England 1 MD_MERs 1A K9N638
Core protein Dengue virus 2 MEM_9FLAV MEM O11875
Methyltransferase Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 MTASE_SARS2 MTASE
Methyltransferase Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 MTASE_SARS2 MTASE
Matrix protein 2 Influenza A virus; strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd MX2_A-H5N1 M Q9Q0L9
Matrix protein VP40 Sudan ebolavirus MX_9MONO VP40 B0LPL6
RING finger protein Z Lassa virus; strain Mouse/Sierra Leone/Josiah/1976; LASV MX_LASSJ Z O73557
Neuraminidase Influenza A virus; strain A/Duck/England/1/1956 H11N6 NA_A-H11N6 NA Q6XV27
Neuraminidase Influenza A virus; strain A/Tern/Australia/G70C/1975 H11N9 NA_A-H11N9 NA P03472
Neuraminidase Influenza A virus; strain A/Duck/Alberta/60/1976 H12N5 NA_A-H12N5 NA A1ILL9
Neuraminidase Influenza A virus; strain A/Whale/Maine/1/1984 H13N9 NA_A-H13N9 NA P05803
Neuraminidase Influenza A virus; A/little yellow-shouldered bat/Guatemala/164/2009; H17N10 NA_A-H17N10 NA H6QM85
Neuraminidase NA_A-H18N11 NA
Neuraminidase Influenza A virus; A/Texas/17/2009; H1N1 NA_A-H1N1 NA C6KP13
Neuraminidase Influenza A virus; strain A/Tokyo/3/1967 H2N2 NA_A-H2N2 NA P06820
Ig heavy chain Mem5 Mus musculus; Mouse NA_A-H3N2 NA P84751
Neuraminidase Influenza A virus; strain A/Duck/Ukraine/1/1963 H3N8 NA_A-H3N8 NA Q07599 CHEMBL4295592 14 / 14
Neuraminidase Influenza A virus; A/American green-winged teal/Washington/195750/2014; H5N1 NA_A-H5N1 NA A0A0C5BL75
Neuraminidase Influenza A virus; A/Shanghai/02/2013; H7N9 NA_A-H7N9 NA R4NFR6
Neuraminidase Influenza B virus; strain B/Lee/1940 NA_INFB NA P03474 CHEMBL3377 372 / 392
Nucleoprotein Andes orthohantavirus NP_9ADNV NP Q80DP9
Nucleoprotein Influenza A virus; strain A/Wilson-Smith/1933 H1N1; Influenza A virus; strain A/WS/1933 H1N1 NP_A-H1N1 NP Q1K9H2
Nucleoprotein Influenza A virus; A/Chicken/Hong Kong/786/97; H5N1 NP_A-H5N1 NP Q9PX50
Nucleoprotein Zaire ebolavirus; strain Mayinga-76; ZEBOV; Zaire Ebola virus NP_EBOZM NP P18272
Nucleoprotein Human coronavirus NL63; HCoV-NL63 NP_HCoV-NL63 N Q6Q1R8
Nucleoprotein Human coronavirus OC43; HCoV-OC43 NP_HCoV-OC43 N P33469 CHEMBL3232681 4 / 4
Nucleoprotein Influenza B virus; B/Managua/4577.01/2008 NP_INFB NP C4LQ26
NP Influenza D virus; D/bovine/France/2986/2012 NP_INFD NP A0A0E3VZU8
Nucleoprotein Lassa virus; strain Mouse/Sierra Leone/Josiah/1976; LASV NP_LASSJ N P13699
Nucleoprotein Severe acute respiratory syndrome coronavirus; SARS-CoV NP_SARS N P59595
NTPase Murine norovirus 1 NS1_9CALI NS1 Q80J95
Non-structural protein 1 Dengue virus 2 NS1_9FLAV NS1 Q6TFL7
Genome polyprotein Dengue virus type 1; strain Nauru/West Pac/1974; DENV-1 NS1_DEN1W NS1 P17763
Core protein Zika virus; ZIKV NS1_ZIKV NS1 A0A109PRQ3
Core protein Dengue virus 2 NS2A_9FLAV NS2A Q9YKL3
Genome polyprotein Dengue virus type 1; strain Nauru/West Pac/1974; DENV-1 NS2B_DEN1W NS2B P17763
Genome polyprotein Dengue virus type 2; strain Puerto Rico/PR159-S1/1969; DENV-2 NS2B_DEN2P NS2B P12823 CHEMBL3308998 78 / 78
Genome polyprotein Zika virus; ZIKV NS2B_ZIKV NS2B Q32ZE1 CHEMBL4523307 20 / 22
Genome polyprotein Zika virus; isolate ZIKV/Human/French Polynesia/10087PF/2013; ZIKV NS2B_ZIKVF NS2B A0A024B7W1
Core protein Dengue virus 4 NS3_9FLAV NS3 F8TEL4
Genome polyprotein Dengue virus type 4; strain Thailand/0348/1991; DENV-4 NS3_DEN4T NS3 Q2YHF0
Genome polyprotein Hepatitis C virus genotype 1a; isolate H77; HCV NS3_HCV1A NS3 P27958 CHEMBL3638344 903 / 903
Genome polyprotein Hepacivirus C NS3_HCV1B NS3 Q91RS4 CHEMBL3988605 24 / 0
Genome polyprotein Hepacivirus C NS3_HCV3A NS3 A0A0B4WYC6
Genome polyprotein Zika virus; ZIKV NS3_ZIKV NS3 Q32ZE1 CHEMBL4523307 20 / 22
Genome polyprotein Hepatitis C virus genotype 1a; isolate 1; HCV NS5B_HCV1A NS5B P26664 CHEMBL4620 243 / 244
Genome polyprotein Hepatitis C virus genotype 1b; isolate BK; HCV NS5B_HCV1B NS5B P26663 CHEMBL6040 50 / 50
Genome polyprotein Hepatitis C virus genotype 2a; isolate JFH-1; HCV NS5B_HCV2A NS5B Q99IB8 CHEMBL4295932 4 / 4
Core protein Dengue virus 2 NS5_9FLAV NS5 H9M652
Genome polyprotein Dengue virus type 3; strain Sri Lanka/1266/2000; DENV-3 NS5_DEN3S POL Q6YMS4
Genome polyprotein Zika virus; ZIKV NS5_ZIKV NS5 Q32ZE1 CHEMBL4523307 20 / 22
Genome polyprotein Zika virus; isolate ZIKV/Human/French Polynesia/10087PF/2013; ZIKV NS5_ZIKVF NS5 A0A024B7W1
NTPase Murine norovirus 1 NS6_9CALI NS6 Q80J95
Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus; SARS-CoV NSP15_SARS REP P0C6X7 CHEMBL5118 357 / 378
Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 NSP15_SARS2 NSP15
Non-structural protein 1 Influenza B virus; strain B/Lee/1940 NSP1_INFB NS P03502
Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus; SARS-CoV NSP1_SARS REP P0C6X7 CHEMBL5118 357 / 378
Replicase polyprotein 1a Human coronavirus 229E; HCoV-229E NSP3_HCoV-229E 1A P0C6U2
Replicase polyprotein 1a Avian infectious bronchitis virus; strain M41; IBV NSP3_IBV 1A P0C6V5
Replicase polyprotein 1ab Murine coronavirus; strain A59; MHV-A59; Murine hepatitis virus NSP3_MHV REP P0C6X9
Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 NSP3_SARS2 NSP3
Replicase polyprotein 1ab Human coronavirus 229E; HCoV-229E NSP9_HCoV-229E REP P0C6X1
Polymerase acidic protein Influenza A virus; A/little yellow-shouldered bat/Guatemala/060/2010; H17N10 PA_A-H17N10 PA H6QM92
Polymerase acidic protein Influenza A virus; strain swl A/California/04/2009 H1N1 PA_A-H1N1 PA C3W5S0
Polymerase acidic protein Influenza A virus; strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd PA_A-H5N1 PA Q9Q0U9
Polymerase acidic protein Influenza A virus; strain A/Puerto Rico/8/1934 H1N1 PA_INFA PA P03433 CHEMBL1169598 788 / 789
Polymerase acidic protein Influenza B virus; B/Memphis/13/2003 PA_INFB PA Q5V8Z9
Polymerase basic protein 2 Influenza A virus; strain A/Beijing/39/1975 H3N2 PB2_A-H3N2 PB2 Q30NP1
Polymerase basic protein 2 Influenza A virus; A/duck/Shantou/4610/2003; H5N1 PB2_A-H5N1 PB2 Q2LG68
Polymerase basic protein 2 Influenza B virus; strain B/Lee/1940 PB2_INFB PB2 Q9QLL6
Polymerase basic protein 2 Influenza A virus; strain A/Beijing/39/1975 H3N2 PB3_A-H3N2 PB2 Q30NP1
Polymerase basic protein 2 Influenza A virus; strain A/Beijing/39/1975 H3N2 PB4_A-H3N2 PB2 Q30NP1
Replicase polyprotein 1a Severe acute respiratory syndrome coronavirus; SARS-CoV PLP_SARS 1A P0C6U8 CHEMBL3927 315 / 329
papain-like protease Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 PLP_SARS2 PLP
RNA-directed RNA polymerase L Lassa mammarenavirus PM_9VIRU L A0A097F4L1
Replicase polyprotein 1ab Feline coronavirus; strain FIPV WSU-79/1146; FCoV PR_FCoV REP Q98VG9 CHEMBL4295624 12 / 12
Replicase polyprotein 1a Human coronavirus 229E; HCoV-229E PR_HCoV-229E 1A P0C6U2
Replicase polyprotein 1a Human coronavirus NL63; HCoV-NL63 PR_HCoV-NL63 1A P0C6U6 CHEMBL3232683 18 / 18
Gag-Pol polyprotein Human immunodeficiency virus type 1 group M subtype B; isolate ARV2/SF2; HIV-1 PR_HIV1 GAG-POL P03369 CHEMBL3638331 20 / 20
Gag-Pol polyprotein Human immunodeficiency virus type 2 subtype A; isolate ROD; HIV-2 PR_HIV2 GAG-POL P04584
Replicase polyprotein 1a Human coronavirus HKU1; isolate N1; HCoV-HKU1 PR_HKU1 1A P0C6U3
Replicase polyprotein 1ab Bat coronavirus HKU4; BtCoV; BtCoV/HKU4/2004 PR_HKU4 REP P0C6W3
Replicase polyprotein 1a Avian infectious bronchitis virus; strain M41; IBV PR_IBV 1A P0C6V5
3C-like proteinase Middle East respiratory syndrome-related coronavirus; MERS-CoV PR_MERs ORF1A V9TU12
3C-like proteinase Porcine epidemic diarrhea virus PR_PEDV ORF1A U6BPB2
Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus; SARS-CoV PR_SARS REP P0C6X7 CHEMBL5118 357 / 378
3C-like protease Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 PR_SARS2 PR
Replicase polyprotein 1a Porcine transmissible gastroenteritis coronavirus; strain Purdue; TGEV PR_TGEV 1A P0C6V2
Norovirus P domain protein Alphatron virus P_9CALI P A0A509GV46
Capsid protein VP1 Norwalk virus; strain GI/Human/United States/Norwalk/1968; Hu/NV/NV/1968/US P_NVN68 ORF2 Q83884
RNA-dependent RNA polymerase Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 RDRP_SARS2 RDRP
Gag-Pol polyprotein Human immunodeficiency virus type 1 group M subtype B; isolate HXB2; HIV-1 RT_HIV1 GAG-POL P04585 CHEMBL3638360 360 / 363
Spike glycoprotein Human coronavirus 229E; HCoV-229E SPIKE_HCoV-229E S P15423
Spike glycoprotein Human coronavirus NL63; HCoV-NL63 SPIKE_HCoV-NL63 S Q6Q1S2
Spike glycoprotein Human coronavirus OC43; HCoV-OC43 SPIKE_HCoV-OC43 S Q696P8
Spike glycoprotein Bat coronavirus HKU4; BtCoV; BtCoV/HKU4/2004 SPIKE_HKU4 S A3EX94
Spike glycoprotein Infectious bronchitis virus SPIKE_IBV SPIKE F4MIW6
Spike glycoprotein Middle East respiratory syndrome-related coronavirus; isolate United Kingdom/H123990006/2012; MERS-CoV; Betacoronavirus England 1 SPIKE_MERs S K9N5Q8
Spike glycoprotein Murine hepatitis virus SPIKE_MHV ORF3 Q9J3E7
Spike protein Deltacoronavirus PDCoV/USA/Ohio137/2014 SPIKE_PDCoV S A0A075E3D7
Spike glycoprotein Severe acute respiratory syndrome coronavirus; SARS-CoV SPIKE_SARS S P59594
Spike glycoprotein Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; SARS-CoV-2 SPIKE_SARS2 S P0DTC2
Capsid protein Murine norovirus 1 VP1_9CALI VP1 Q2V8W4
Capsid protein VP1 Norwalk virus; strain GI/Human/United States/Norwalk/1968; Hu/NV/NV/1968/US VP1_NVN68 ORF2 Q83884
Membrane-associated protein VP24 Reston ebolavirus; strain Philippines-96; REBOV; Reston Ebola virus VP24_EBORE VP24 Q91DD5
Membrane-associated protein VP24 Sudan ebolavirus; strain Human/Uganda/Gulu/2000; SEBOV; Sudan Ebola virus VP24_EBOSU VP24 Q5XX02
Membrane-associated protein VP24 Zaire ebolavirus; strain Mayinga-76; ZEBOV; Zaire Ebola virus VP24_EBOZM VP24 Q05322
Minor nucleoprotein VP30 Mengla dianlovirus VP30_9MONO VP30 A0A3S8UVN5
Transcriptional activator VP30 Zaire ebolavirus; strain Kikwit-95; ZEBOV; Zaire Ebola virus VP30_EBOZ5 VP30 Q77DJ5
Transcriptional activator VP30 Zaire ebolavirus; strain Mayinga-76; ZEBOV; Zaire Ebola virus VP30_EBOZM VP30 Q05323
Polymerase cofactor VP35 Reston ebolavirus; strain Reston-89; REBOV; Reston Ebola virus VP35_EBORR VP35 Q8JPY0
Polymerase cofactor VP35 Zaire ebolavirus; strain Mayinga-76; ZEBOV; Zaire Ebola virus VP35_EBOZM VP35 Q05127
Matrix protein VP40 Zaire ebolavirus; strain Mayinga-76; ZEBOV; Zaire Ebola virus VP40_EBOZM VP40 Q05128