Drug combination for HCV treatment #387 Output Download CSV

Gene Protein
 
  The docking scores are in the AutoDock Vina metric.
Ligand Protein Symbol Approved Name Docking Scores Similarity
Score 		Best Match
Model 1 Model 2 Model 3
Brequinar 2A_HE71 Genome polyprotein -8.70 N/A N/A N/A N/A
Niclosamide 2A_HE71 Genome polyprotein -6.94 N/A N/A N/A N/A
Sofosbuvir 2A_HE71 Genome polyprotein -8.27 N/A N/A N/A N/A
Brequinar 2A_HE71M Genome polyprotein -8.76 N/A N/A N/A N/A
Niclosamide 2A_HE71M Genome polyprotein -7.01 N/A N/A N/A N/A
Sofosbuvir 2A_HE71M Genome polyprotein -8.16 N/A N/A N/A N/A
Brequinar 2C_HE71 Genome polyprotein -6.05 -7.72 N/A N/A N/A
Niclosamide 2C_HE71 Genome polyprotein -6.73 -6.90 N/A N/A N/A
Sofosbuvir 2C_HE71 Genome polyprotein -6.35 -6.32 N/A N/A N/A
Brequinar 3A_9ENTO Genome polyprotein -7.17 N/A N/A N/A N/A
Niclosamide 3A_9ENTO Genome polyprotein -5.77 N/A N/A N/A N/A
Sofosbuvir 3A_9ENTO Genome polyprotein -6.08 N/A N/A N/A N/A
Brequinar 3A_HE71M Genome polyprotein -6.92 N/A N/A N/A N/A
Niclosamide 3A_HE71M Genome polyprotein -5.72 N/A N/A N/A N/A
Sofosbuvir 3A_HE71M Genome polyprotein -5.83 N/A N/A N/A N/A
Brequinar 3A_HED68 Genome polyprotein -6.75 N/A N/A N/A N/A
Niclosamide 3A_HED68 Genome polyprotein -5.82 N/A N/A N/A N/A
Sofosbuvir 3A_HED68 Genome polyprotein -6.19 N/A N/A N/A N/A
Brequinar 3C_HE71 Genome polyprotein -7.50 -7.57 N/A N/A N/A
Niclosamide 3C_HE71 Genome polyprotein -5.97 -6.49 N/A N/A N/A
Sofosbuvir 3C_HE71 Genome polyprotein -6.36 -6.97 N/A N/A N/A
Brequinar 3C_HED68 Genome polyprotein -6.75 N/A N/A N/A N/A
Niclosamide 3C_HED68 Genome polyprotein -6.00 N/A N/A N/A N/A
Sofosbuvir 3C_HED68 Genome polyprotein -6.12 N/A N/A N/A N/A
Brequinar 3D_HE71 Genome polyprotein -9.25 N/A N/A N/A N/A
Niclosamide 3D_HE71 Genome polyprotein -7.72 N/A N/A N/A N/A
Sofosbuvir 3D_HE71 Genome polyprotein -7.94 N/A N/A N/A N/A
Brequinar 3D_HED68 Genome polyprotein -10.13 N/A N/A N/A N/A
Niclosamide 3D_HED68 Genome polyprotein -7.67 N/A N/A N/A N/A
Sofosbuvir 3D_HED68 Genome polyprotein -8.62 N/A N/A N/A N/A
Brequinar ACE2_HUMAN angiotensin converting enzyme 2 -10.53 N/A N/A 23.63% CHEMBL1240682
Niclosamide ACE2_HUMAN angiotensin converting enzyme 2 -8.90 N/A N/A 21.83% CHEMBL253224
Sofosbuvir ACE2_HUMAN angiotensin converting enzyme 2 -9.47 N/A N/A 21.52% CHEMBL1240682
Brequinar CAPSD_9CALI Capsid protein -9.11 -8.12 -9.30 N/A N/A
Niclosamide CAPSD_9CALI Capsid protein -7.59 -6.94 -8.45 N/A N/A
Sofosbuvir CAPSD_9CALI Capsid protein -8.75 -7.52 -7.95 N/A N/A
Brequinar CAPSD_9ENTO Genome polyprotein -12.66 N/A N/A N/A N/A
Niclosamide CAPSD_9ENTO Genome polyprotein -10.19 N/A N/A N/A N/A
Sofosbuvir CAPSD_9ENTO Genome polyprotein -9.33 N/A N/A N/A N/A
Brequinar CAPSD_DEN2P Genome polyprotein -9.22 N/A N/A N/A N/A
Niclosamide CAPSD_DEN2P Genome polyprotein -6.75 N/A N/A N/A N/A
Sofosbuvir CAPSD_DEN2P Genome polyprotein -7.22 N/A N/A N/A N/A
Brequinar CAPSD_HCV77 Genome polyprotein -6.04 N/A N/A 38.50% CHEMBL3901862
Niclosamide CAPSD_HCV77 Genome polyprotein -5.06 N/A N/A 34.52% CHEMBL4106916
Sofosbuvir CAPSD_HCV77 Genome polyprotein -4.89 N/A N/A 80.72% CHEMBL3696815
Brequinar CAPSD_HED68 Capsid protein VP0 -11.30 -10.63 N/A N/A N/A
Niclosamide CAPSD_HED68 Capsid protein VP0 -8.55 -8.42 N/A N/A N/A
Sofosbuvir CAPSD_HED68 Capsid protein VP0 -9.42 -9.55 N/A N/A N/A
Brequinar CAPSD_ZIKV Core protein -7.26 -8.22 N/A N/A N/A
Niclosamide CAPSD_ZIKV Core protein -5.59 -5.99 N/A N/A N/A
Sofosbuvir CAPSD_ZIKV Core protein -6.38 -6.90 N/A N/A N/A
Brequinar DPM_HHV1K DNA polymerase catalytic subunit -8.41 N/A N/A 26.38% CHEMBL479371
Niclosamide DPM_HHV1K DNA polymerase catalytic subunit -8.04 N/A N/A 23.35% CHEMBL481172
Sofosbuvir DPM_HHV1K DNA polymerase catalytic subunit -8.58 N/A N/A 19.82% CHEMBL481172
Brequinar E1_9HEPC Envelope glycoprotein E1 -7.25 N/A N/A N/A N/A
Niclosamide E1_9HEPC Envelope glycoprotein E1 -5.34 N/A N/A N/A N/A
Sofosbuvir E1_9HEPC Envelope glycoprotein E1 -6.04 N/A N/A N/A N/A
Brequinar E1_HCV77 Genome polyprotein -5.26 N/A N/A 38.50% CHEMBL3901862
Niclosamide E1_HCV77 Genome polyprotein -4.47 N/A N/A 34.52% CHEMBL4106916
Sofosbuvir E1_HCV77 Genome polyprotein -4.58 N/A N/A 80.72% CHEMBL3696815
Brequinar E1_HCVJ1 Genome polyprotein -5.77 N/A N/A N/A N/A
Niclosamide E1_HCVJ1 Genome polyprotein -5.05 N/A N/A N/A N/A
Sofosbuvir E1_HCVJ1 Genome polyprotein -5.12 N/A N/A N/A N/A
Brequinar E2_9HEPC Core protein precursor -9.87 N/A N/A N/A N/A
Niclosamide E2_9HEPC Core protein precursor -8.07 N/A N/A N/A N/A
Sofosbuvir E2_9HEPC Core protein precursor -8.44 N/A N/A N/A N/A
Brequinar E2_HCV77 Genome polyprotein -7.52 N/A N/A 38.50% CHEMBL3901862
Niclosamide E2_HCV77 Genome polyprotein -6.14 N/A N/A 34.52% CHEMBL4106916
Sofosbuvir E2_HCV77 Genome polyprotein -6.55 N/A N/A 80.72% CHEMBL3696815
Brequinar ENV_9FLAV Envelope protein E -6.50 N/A N/A N/A N/A
Niclosamide ENV_9FLAV Envelope protein E -5.51 N/A N/A N/A N/A
Sofosbuvir ENV_9FLAV Envelope protein E -5.24 N/A N/A N/A N/A
Brequinar ENV_DEN1B Genome polyprotein -6.58 N/A N/A N/A N/A
Niclosamide ENV_DEN1B Genome polyprotein -5.38 N/A N/A N/A N/A
Sofosbuvir ENV_DEN1B Genome polyprotein -4.95 N/A N/A N/A N/A
Brequinar ENV_DEN2P Genome polyprotein -8.17 N/A N/A N/A N/A
Niclosamide ENV_DEN2P Genome polyprotein -6.64 N/A N/A N/A N/A
Sofosbuvir ENV_DEN2P Genome polyprotein -6.69 N/A N/A N/A N/A
Brequinar ENV_DEN3P Genome polyprotein -7.09 N/A N/A N/A N/A
Niclosamide ENV_DEN3P Genome polyprotein -6.43 N/A N/A N/A N/A
Sofosbuvir ENV_DEN3P Genome polyprotein -6.06 N/A N/A N/A N/A
Brequinar ENV_HHV2H Envelope glycoprotein H -8.20 N/A N/A N/A N/A
Niclosamide ENV_HHV2H Envelope glycoprotein H -6.81 N/A N/A N/A N/A
Sofosbuvir ENV_HHV2H Envelope glycoprotein H -6.72 N/A N/A N/A N/A
Brequinar ENV_ZIKV Core protein -6.87 N/A N/A N/A N/A
Niclosamide ENV_ZIKV Core protein -6.49 N/A N/A N/A N/A
Sofosbuvir ENV_ZIKV Core protein -5.99 N/A N/A N/A N/A
Brequinar ENV_ZIKVK Genome polyprotein -7.26 N/A N/A N/A N/A
Niclosamide ENV_ZIKVK Genome polyprotein -6.56 N/A N/A N/A N/A
Sofosbuvir ENV_ZIKVK Genome polyprotein -6.81 N/A N/A N/A N/A
Brequinar G1_ADNV Envelope polyprotein -4.49 -8.43 -8.36 N/A N/A
Niclosamide G1_ADNV Envelope polyprotein -4.99 -6.80 -7.07 N/A N/A
Sofosbuvir G1_ADNV Envelope polyprotein -4.52 -7.04 -6.55 N/A N/A
Brequinar G2_ADNV Envelope polyprotein -9.69 -9.11 -7.46 N/A N/A
Niclosamide G2_ADNV Envelope polyprotein -7.68 -7.70 -6.64 N/A N/A
Sofosbuvir G2_ADNV Envelope polyprotein -8.50 -7.61 -7.14 N/A N/A
Brequinar GB_HHV11 Envelope glycoprotein B -8.41 N/A N/A N/A N/A
Niclosamide GB_HHV11 Envelope glycoprotein B -7.13 N/A N/A N/A N/A
Sofosbuvir GB_HHV11 Envelope glycoprotein B -7.28 N/A N/A N/A N/A
Brequinar GB_HHV1K Envelope glycoprotein B -7.97 -8.18 N/A N/A N/A
Niclosamide GB_HHV1K Envelope glycoprotein B -6.93 -7.18 N/A N/A N/A
Sofosbuvir GB_HHV1K Envelope glycoprotein B -7.29 -7.08 N/A N/A N/A
Brequinar GD_9ALPH Glycoprotein D -8.26 -7.47 N/A N/A N/A
Niclosamide GD_9ALPH Glycoprotein D -7.11 -7.93 N/A N/A N/A
Sofosbuvir GD_9ALPH Glycoprotein D -7.19 -6.29 N/A N/A N/A
Brequinar GD_HHV1 Glycoprotein D -7.40 N/A N/A N/A N/A
Niclosamide GD_HHV1 Glycoprotein D -6.44 N/A N/A N/A N/A
Sofosbuvir GD_HHV1 Glycoprotein D -6.55 N/A N/A N/A N/A
Brequinar GP160_HIV1 Envelope glycoprotein gp160 -8.75 -6.78 -8.75 N/A N/A
Niclosamide GP160_HIV1 Envelope glycoprotein gp160 -6.14 -7.02 -6.71 N/A N/A
Sofosbuvir GP160_HIV1 Envelope glycoprotein gp160 -6.75 -6.41 -6.96 N/A N/A
Brequinar GP160_HIV2 Envelope glycoprotein gp160 -7.85 N/A N/A N/A N/A
Niclosamide GP160_HIV2 Envelope glycoprotein gp160 -6.29 N/A N/A N/A N/A
Sofosbuvir GP160_HIV2 Envelope glycoprotein gp160 -6.39 N/A N/A N/A N/A
Brequinar GP_EBOV Envelope glycoprotein -8.80 -8.87 -9.58 25.81% CHEMBL4640931
Niclosamide GP_EBOV Envelope glycoprotein -7.39 -7.48 -7.07 39.39% CHEMBL4640931
Sofosbuvir GP_EBOV Envelope glycoprotein -7.67 -7.51 -7.96 22.41% CHEMBL3125895
Brequinar GP_LASSJ Pre-glycoprotein polyprotein GP complex -7.22 -7.07 N/A N/A N/A
Niclosamide GP_LASSJ Pre-glycoprotein polyprotein GP complex -6.72 -7.09 N/A N/A N/A
Sofosbuvir GP_LASSJ Pre-glycoprotein polyprotein GP complex -6.11 -6.57 N/A N/A N/A
Brequinar HA_A-H10N7 Hemagglutinin -7.44 N/A N/A N/A N/A
Niclosamide HA_A-H10N7 Hemagglutinin -6.81 N/A N/A N/A N/A
Sofosbuvir HA_A-H10N7 Hemagglutinin -7.40 N/A N/A N/A N/A
Brequinar HA_A-H10N8 Hemagglutinin -7.78 N/A N/A N/A N/A
Niclosamide HA_A-H10N8 Hemagglutinin -6.14 N/A N/A N/A N/A
Sofosbuvir HA_A-H10N8 Hemagglutinin -6.32 N/A N/A N/A N/A
Brequinar HA_A-H13N6 Hemagglutinin -7.16 N/A N/A N/A N/A
Niclosamide HA_A-H13N6 Hemagglutinin -6.66 N/A N/A N/A N/A
Sofosbuvir HA_A-H13N6 Hemagglutinin -6.67 N/A N/A N/A N/A
Brequinar HA_A-H14N6 Hemagglutinin -7.88 N/A N/A N/A N/A
Niclosamide HA_A-H14N6 Hemagglutinin -7.46 N/A N/A N/A N/A
Sofosbuvir HA_A-H14N6 Hemagglutinin -6.27 N/A N/A N/A N/A
Brequinar HA_A-H15N9 Hemagglutinin -7.08 N/A N/A N/A N/A
Niclosamide HA_A-H15N9 Hemagglutinin -6.98 N/A N/A N/A N/A
Sofosbuvir HA_A-H15N9 Hemagglutinin -6.69 N/A N/A N/A N/A
Brequinar HA_A-H17N10 Hemagglutinin -6.82 N/A N/A N/A N/A
Niclosamide HA_A-H17N10 Hemagglutinin -6.36 N/A N/A N/A N/A
Sofosbuvir HA_A-H17N10 Hemagglutinin -6.41 N/A N/A N/A N/A
Brequinar HA_A-H18N11 Hemagglutinin -6.85 N/A N/A N/A N/A
Niclosamide HA_A-H18N11 Hemagglutinin -5.32 N/A N/A N/A N/A
Sofosbuvir HA_A-H18N11 Hemagglutinin -6.39 N/A N/A N/A N/A
Brequinar HA_A-H1N1 Hemagglutinin -7.84 -7.45 N/A N/A N/A
Niclosamide HA_A-H1N1 Hemagglutinin -6.41 -6.15 N/A N/A N/A
Sofosbuvir HA_A-H1N1 Hemagglutinin -6.60 -6.50 N/A N/A N/A
Brequinar HA_A-H2N2 Hemagglutinin -7.28 -7.94 N/A N/A N/A
Niclosamide HA_A-H2N2 Hemagglutinin -6.11 -5.84 N/A N/A N/A
Sofosbuvir HA_A-H2N2 Hemagglutinin -6.52 -6.42 N/A N/A N/A
Brequinar HA_A-H3N2 Hemagglutinin -7.82 -7.84 -7.96 N/A N/A
Niclosamide HA_A-H3N2 Hemagglutinin -6.47 -6.40 -6.24 N/A N/A
Sofosbuvir HA_A-H3N2 Hemagglutinin -7.02 -6.87 -6.51 N/A N/A
Brequinar HA_A-H3N8 Hemagglutinin -7.51 -7.72 -7.56 N/A N/A
Niclosamide HA_A-H3N8 Hemagglutinin -5.92 -5.86 -6.24 N/A N/A
Sofosbuvir HA_A-H3N8 Hemagglutinin -6.36 -6.59 -6.47 N/A N/A
Brequinar HA_A-H5N1 Hemagglutinin -7.85 -7.92 -7.15 N/A N/A
Niclosamide HA_A-H5N1 Hemagglutinin -6.85 -6.77 -6.59 N/A N/A
Sofosbuvir HA_A-H5N1 Hemagglutinin -6.81 -7.05 -7.14 N/A N/A
Brequinar HA_A-H5N3 Hemagglutinin -7.97 -7.20 N/A N/A N/A
Niclosamide HA_A-H5N3 Hemagglutinin -6.43 -6.62 N/A N/A N/A
Sofosbuvir HA_A-H5N3 Hemagglutinin -6.75 -6.47 N/A N/A N/A
Brequinar HA_A-H6N1 Hemagglutinin -7.78 N/A N/A N/A N/A
Niclosamide HA_A-H6N1 Hemagglutinin -6.14 N/A N/A N/A N/A
Sofosbuvir HA_A-H6N1 Hemagglutinin -6.32 N/A N/A N/A N/A
Brequinar HA_A-H6N6 Hemagglutinin -6.79 N/A N/A N/A N/A
Niclosamide HA_A-H6N6 Hemagglutinin -6.72 N/A N/A N/A N/A
Sofosbuvir HA_A-H6N6 Hemagglutinin -6.74 N/A N/A N/A N/A
Brequinar HA_A-H7N2 Hemagglutinin -6.90 -6.52 -6.57 N/A N/A
Niclosamide HA_A-H7N2 Hemagglutinin -6.36 -6.13 -5.97 N/A N/A
Sofosbuvir HA_A-H7N2 Hemagglutinin -7.31 -5.77 -7.37 N/A N/A
Brequinar HA_A-H7N7 Hemagglutinin -6.69 -7.17 N/A N/A N/A
Niclosamide HA_A-H7N7 Hemagglutinin -6.27 -6.86 N/A N/A N/A
Sofosbuvir HA_A-H7N7 Hemagglutinin -6.11 -7.50 N/A N/A N/A
Brequinar HA_A-H7N9 Hemagglutinin -7.65 N/A N/A N/A N/A
Niclosamide HA_A-H7N9 Hemagglutinin -6.63 N/A N/A N/A N/A
Sofosbuvir HA_A-H7N9 Hemagglutinin -6.86 N/A N/A N/A N/A
Brequinar HA_INFB Hemagglutinin -7.64 -6.99 N/A N/A N/A
Niclosamide HA_INFB Hemagglutinin -6.54 -6.07 N/A N/A N/A
Sofosbuvir HA_INFB Hemagglutinin -6.58 -6.56 N/A N/A N/A
Brequinar HA_INFD Hemagglutinin-esterase-fusion glycoprotein -6.97 N/A N/A N/A N/A
Niclosamide HA_INFD Hemagglutinin-esterase-fusion glycoprotein -5.80 N/A N/A N/A N/A
Sofosbuvir HA_INFD Hemagglutinin-esterase-fusion glycoprotein -5.88 N/A N/A N/A N/A
Brequinar HE_BCV Hemagglutinin-esterase -7.17 -7.08 N/A N/A N/A
Niclosamide HE_BCV Hemagglutinin-esterase -6.65 -6.38 N/A N/A N/A
Sofosbuvir HE_BCV Hemagglutinin-esterase -6.79 -6.77 N/A N/A N/A
Brequinar HE_HCoV-OC43 Hemagglutinin-esterase -6.81 N/A N/A N/A N/A
Niclosamide HE_HCoV-OC43 Hemagglutinin-esterase -6.24 N/A N/A N/A N/A
Sofosbuvir HE_HCoV-OC43 Hemagglutinin-esterase -6.02 N/A N/A N/A N/A
Brequinar HE_MHV Hemagglutinin-esterase -7.36 N/A N/A N/A N/A
Niclosamide HE_MHV Hemagglutinin-esterase -5.69 N/A N/A N/A N/A
Sofosbuvir HE_MHV Hemagglutinin-esterase -6.24 N/A N/A N/A N/A
Brequinar IN_HIV1 Gag-Pol polyprotein -6.91 -7.09 N/A N/A N/A
Niclosamide IN_HIV1 Gag-Pol polyprotein -5.67 -6.03 N/A N/A N/A
Sofosbuvir IN_HIV1 Gag-Pol polyprotein -5.28 -5.65 N/A N/A N/A
Brequinar MD_HKU4 Replicase polyprotein 1ab -8.98 -9.21 -9.72 N/A N/A
Niclosamide MD_HKU4 Replicase polyprotein 1ab -8.77 -8.59 -8.59 N/A N/A
Sofosbuvir MD_HKU4 Replicase polyprotein 1ab -8.27 -7.82 -8.44 N/A N/A
Brequinar MD_MERs Replicase polyprotein 1a -10.02 -9.06 N/A N/A N/A
Niclosamide MD_MERs Replicase polyprotein 1a -9.11 -8.32 N/A N/A N/A
Sofosbuvir MD_MERs Replicase polyprotein 1a -8.75 -8.63 N/A N/A N/A
Brequinar MEM_9FLAV Core protein -6.80 N/A N/A N/A N/A
Niclosamide MEM_9FLAV Core protein -5.84 N/A N/A N/A N/A
Sofosbuvir MEM_9FLAV Core protein -6.07 N/A N/A N/A N/A
Brequinar MTASE_SARS2 Methyltransferase -7.22 N/A N/A N/A N/A
Brequinar MTASE_SARS2 Methyltransferase -9.16 N/A N/A N/A N/A
Niclosamide MTASE_SARS2 Methyltransferase -6.07 N/A N/A N/A N/A
Niclosamide MTASE_SARS2 Methyltransferase -7.94 N/A N/A N/A N/A
Sofosbuvir MTASE_SARS2 Methyltransferase -6.21 N/A N/A N/A N/A
Sofosbuvir MTASE_SARS2 Methyltransferase -7.93 N/A N/A N/A N/A
Brequinar MX2_A-H5N1 Matrix protein 2 5.91 N/A N/A N/A N/A
Niclosamide MX2_A-H5N1 Matrix protein 2 -5.59 N/A N/A N/A N/A
Sofosbuvir MX2_A-H5N1 Matrix protein 2 -6.51 N/A N/A N/A N/A
Brequinar MX_9MONO Matrix protein VP40 -9.81 N/A N/A N/A N/A
Niclosamide MX_9MONO Matrix protein VP40 -7.63 N/A N/A N/A N/A
Sofosbuvir MX_9MONO Matrix protein VP40 -8.80 N/A N/A N/A N/A
Brequinar MX_LASSJ RING finger protein Z -7.07 N/A N/A N/A N/A
Niclosamide MX_LASSJ RING finger protein Z -5.78 N/A N/A N/A N/A
Sofosbuvir MX_LASSJ RING finger protein Z -6.02 N/A N/A N/A N/A
Brequinar NA_A-H11N6 Neuraminidase -10.06 -9.88 -8.91 N/A N/A
Niclosamide NA_A-H11N6 Neuraminidase -7.18 -7.37 -6.90 N/A N/A
Sofosbuvir NA_A-H11N6 Neuraminidase -8.02 -8.45 -8.25 N/A N/A
Brequinar NA_A-H11N9 Neuraminidase -7.86 -8.12 -9.00 N/A N/A
Niclosamide NA_A-H11N9 Neuraminidase -6.97 -7.08 -7.03 N/A N/A
Sofosbuvir NA_A-H11N9 Neuraminidase -6.27 -7.91 -8.15 N/A N/A
Brequinar NA_A-H12N5 Neuraminidase -8.31 -8.34 -9.76 N/A N/A
Niclosamide NA_A-H12N5 Neuraminidase -6.89 -7.45 -7.45 N/A N/A
Sofosbuvir NA_A-H12N5 Neuraminidase -7.70 -8.68 -8.48 N/A N/A
Brequinar NA_A-H13N9 Neuraminidase -7.50 N/A N/A N/A N/A
Niclosamide NA_A-H13N9 Neuraminidase -7.08 N/A N/A N/A N/A
Sofosbuvir NA_A-H13N9 Neuraminidase -5.98 N/A N/A N/A N/A
Brequinar NA_A-H17N10 Neuraminidase -7.95 N/A N/A N/A N/A
Niclosamide NA_A-H17N10 Neuraminidase -6.76 N/A N/A N/A N/A
Sofosbuvir NA_A-H17N10 Neuraminidase -7.34 N/A N/A N/A N/A
Brequinar NA_A-H18N11 Neuraminidase -7.76 N/A N/A N/A N/A
Niclosamide NA_A-H18N11 Neuraminidase -6.59 N/A N/A N/A N/A
Sofosbuvir NA_A-H18N11 Neuraminidase -7.39 N/A N/A N/A N/A
Brequinar NA_A-H1N1 Neuraminidase -8.27 N/A N/A N/A N/A
Niclosamide NA_A-H1N1 Neuraminidase -6.88 N/A N/A N/A N/A
Sofosbuvir NA_A-H1N1 Neuraminidase -7.70 N/A N/A N/A N/A
Brequinar NA_A-H2N2 Neuraminidase -7.91 -8.10 -8.12 N/A N/A
Niclosamide NA_A-H2N2 Neuraminidase -6.96 -7.08 -6.89 N/A N/A
Sofosbuvir NA_A-H2N2 Neuraminidase -7.92 -8.57 -7.45 N/A N/A
Brequinar NA_A-H3N2 Ig heavy chain Mem5 -9.48 -7.99 N/A N/A N/A
Niclosamide NA_A-H3N2 Ig heavy chain Mem5 -7.14 -6.73 N/A N/A N/A
Sofosbuvir NA_A-H3N2 Ig heavy chain Mem5 -7.73 -7.27 N/A N/A N/A
Brequinar NA_A-H3N8 Neuraminidase -8.03 -8.85 -8.08 17.29% CHEMBL4288395
Niclosamide NA_A-H3N8 Neuraminidase -6.51 -7.38 -6.84 23.12% CHEMBL4292576
Sofosbuvir NA_A-H3N8 Neuraminidase -8.27 -8.22 -8.43 19.67% CHEMBL4288395
Brequinar NA_A-H5N1 Neuraminidase -8.30 N/A N/A N/A N/A
Niclosamide NA_A-H5N1 Neuraminidase -7.26 N/A N/A N/A N/A
Sofosbuvir NA_A-H5N1 Neuraminidase -8.38 N/A N/A N/A N/A
Brequinar NA_A-H7N9 Neuraminidase -8.72 -8.10 -7.86 N/A N/A
Niclosamide NA_A-H7N9 Neuraminidase -6.73 -7.20 -7.10 N/A N/A
Sofosbuvir NA_A-H7N9 Neuraminidase -7.61 -7.71 -7.83 N/A N/A
Brequinar NA_INFB Neuraminidase -8.22 -8.25 N/A 16.51% CHEMBL4175983
Niclosamide NA_INFB Neuraminidase -6.99 -7.23 N/A 28.89% CHEMBL4161935
Sofosbuvir NA_INFB Neuraminidase -7.93 -7.72 N/A 21.67% CHEMBL4128362
Brequinar NP_9ADNV Nucleoprotein -6.05 -10.02 N/A N/A N/A
Niclosamide NP_9ADNV Nucleoprotein -4.65 -8.02 N/A N/A N/A
Sofosbuvir NP_9ADNV Nucleoprotein -5.09 -7.70 N/A N/A N/A
Brequinar NP_A-H1N1 Nucleoprotein -7.79 -8.15 -7.73 N/A N/A
Niclosamide NP_A-H1N1 Nucleoprotein -6.05 -6.41 -7.76 N/A N/A
Sofosbuvir NP_A-H1N1 Nucleoprotein -5.78 -8.02 -6.37 N/A N/A
Brequinar NP_A-H5N1 Nucleoprotein -7.22 N/A N/A N/A N/A
Niclosamide NP_A-H5N1 Nucleoprotein -6.79 N/A N/A N/A N/A
Sofosbuvir NP_A-H5N1 Nucleoprotein -6.44 N/A N/A N/A N/A
Brequinar NP_EBOZM Nucleoprotein -8.20 -7.62 -7.74 N/A N/A
Niclosamide NP_EBOZM Nucleoprotein -6.31 -6.45 -6.74 N/A N/A
Sofosbuvir NP_EBOZM Nucleoprotein -6.65 -6.63 -6.75 N/A N/A
Brequinar NP_HCoV-NL63 Nucleoprotein -7.60 N/A N/A N/A N/A
Niclosamide NP_HCoV-NL63 Nucleoprotein -6.93 N/A N/A N/A N/A
Sofosbuvir NP_HCoV-NL63 Nucleoprotein -7.52 N/A N/A N/A N/A
Brequinar NP_HCoV-OC43 Nucleoprotein -10.43 -8.65 -8.26 21.80% CHEMBL3233481
Niclosamide NP_HCoV-OC43 Nucleoprotein -8.87 -7.60 -6.60 33.63% CHEMBL3233481
Sofosbuvir NP_HCoV-OC43 Nucleoprotein -7.75 -7.44 -7.37 12.03% CHEMBL3233481
Brequinar NP_INFB Nucleoprotein -6.99 N/A N/A N/A N/A
Niclosamide NP_INFB Nucleoprotein -5.13 N/A N/A N/A N/A
Sofosbuvir NP_INFB Nucleoprotein -5.35 N/A N/A N/A N/A
Brequinar NP_INFD NP -6.41 N/A N/A N/A N/A
Niclosamide NP_INFD NP -5.16 N/A N/A N/A N/A
Sofosbuvir NP_INFD NP -5.66 N/A N/A N/A N/A
Brequinar NP_LASSJ Nucleoprotein -11.42 -11.36 -5.47 N/A N/A
Niclosamide NP_LASSJ Nucleoprotein -9.45 -9.54 -4.96 N/A N/A
Sofosbuvir NP_LASSJ Nucleoprotein -9.60 -9.92 -5.52 N/A N/A
Brequinar NP_SARS Nucleoprotein -9.07 N/A N/A N/A N/A
Niclosamide NP_SARS Nucleoprotein -7.36 N/A N/A N/A N/A
Sofosbuvir NP_SARS Nucleoprotein -6.75 N/A N/A N/A N/A
Brequinar NS1_9CALI NTPase -6.89 -6.17 -7.04 N/A N/A
Niclosamide NS1_9CALI NTPase -6.03 -5.31 -6.66 N/A N/A
Sofosbuvir NS1_9CALI NTPase -5.82 -5.62 -7.32 N/A N/A
Brequinar NS1_9FLAV Non-structural protein 1 -6.38 N/A N/A N/A N/A
Niclosamide NS1_9FLAV Non-structural protein 1 -6.41 N/A N/A N/A N/A
Sofosbuvir NS1_9FLAV Non-structural protein 1 -6.12 N/A N/A N/A N/A
Brequinar NS1_DEN1W Genome polyprotein -6.84 N/A N/A N/A N/A
Niclosamide NS1_DEN1W Genome polyprotein -5.51 N/A N/A N/A N/A
Sofosbuvir NS1_DEN1W Genome polyprotein -5.81 N/A N/A N/A N/A
Brequinar NS1_ZIKV Core protein 7.94 -8.43 -8.36 N/A N/A
Niclosamide NS1_ZIKV Core protein -5.20 -7.43 -6.98 N/A N/A
Sofosbuvir NS1_ZIKV Core protein -0.00 -6.67 -7.14 N/A N/A
Brequinar NS2A_9FLAV Core protein -5.38 N/A N/A N/A N/A
Niclosamide NS2A_9FLAV Core protein -4.92 N/A N/A N/A N/A
Sofosbuvir NS2A_9FLAV Core protein -4.58 N/A N/A N/A N/A
Brequinar NS2B_DEN1W Genome polyprotein -8.49 N/A N/A N/A N/A
Niclosamide NS2B_DEN1W Genome polyprotein -7.23 N/A N/A N/A N/A
Sofosbuvir NS2B_DEN1W Genome polyprotein -7.44 N/A N/A N/A N/A
Brequinar NS2B_DEN2P Genome polyprotein -9.26 -8.58 N/A N/A N/A
Niclosamide NS2B_DEN2P Genome polyprotein -6.85 -7.88 N/A N/A N/A
Sofosbuvir NS2B_DEN2P Genome polyprotein -7.48 -7.19 N/A N/A N/A
Brequinar NS2B_ZIKV Genome polyprotein -8.55 -8.41 N/A N/A N/A
Niclosamide NS2B_ZIKV Genome polyprotein -7.35 -7.29 N/A N/A N/A
Sofosbuvir NS2B_ZIKV Genome polyprotein -7.61 -7.55 N/A N/A N/A
Brequinar NS2B_ZIKVF Genome polyprotein -8.47 N/A N/A N/A N/A
Niclosamide NS2B_ZIKVF Genome polyprotein -6.75 N/A N/A N/A N/A
Sofosbuvir NS2B_ZIKVF Genome polyprotein -7.87 N/A N/A N/A N/A
Brequinar NS3_9FLAV Core protein -9.05 N/A N/A N/A N/A
Niclosamide NS3_9FLAV Core protein -7.61 N/A N/A N/A N/A
Sofosbuvir NS3_9FLAV Core protein -9.39 N/A N/A N/A N/A
Brequinar NS3_DEN4T Genome polyprotein -9.45 -9.37 N/A N/A N/A
Niclosamide NS3_DEN4T Genome polyprotein -8.54 -7.61 N/A N/A N/A
Sofosbuvir NS3_DEN4T Genome polyprotein -9.12 -8.49 N/A N/A N/A
Brequinar NS3_HCV1A Genome polyprotein -8.35 -7.20 -8.68 38.50% CHEMBL3901862
Niclosamide NS3_HCV1A Genome polyprotein -6.65 -6.37 -7.34 34.52% CHEMBL4106916
Sofosbuvir NS3_HCV1A Genome polyprotein -6.45 -6.01 -8.24 80.72% CHEMBL3696815
Brequinar NS3_HCV1B Genome polyprotein -9.75 -9.01 -7.42 25.30% CHEMBL1170417
Niclosamide NS3_HCV1B Genome polyprotein -7.58 -7.87 -6.29 21.39% CHEMBL3954962
Sofosbuvir NS3_HCV1B Genome polyprotein -9.09 -8.43 -5.98 21.16% CHEMBL3125634
Brequinar NS3_HCV3A Genome polyprotein -7.76 -7.72 -7.69 N/A N/A
Niclosamide NS3_HCV3A Genome polyprotein -6.20 -6.20 -7.22 N/A N/A
Sofosbuvir NS3_HCV3A Genome polyprotein -6.61 -7.23 -7.40 N/A N/A
Brequinar NS3_ZIKV Genome polyprotein -9.37 N/A N/A N/A N/A
Niclosamide NS3_ZIKV Genome polyprotein -7.54 N/A N/A N/A N/A
Sofosbuvir NS3_ZIKV Genome polyprotein -9.06 N/A N/A N/A N/A
Brequinar NS5B_HCV1A Genome polyprotein -8.94 -9.83 -9.63 30.70% CHEMBL353549
Niclosamide NS5B_HCV1A Genome polyprotein -7.70 -8.53 -7.88 27.52% CHEMBL176058
Sofosbuvir NS5B_HCV1A Genome polyprotein -8.51 -8.82 -8.94 23.01% CHEMBL3644940
Brequinar NS5B_HCV1B Genome polyprotein -9.48 -9.03 -8.36 32.02% CHEMBL213832
Niclosamide NS5B_HCV1B Genome polyprotein -7.43 -7.95 -7.68 31.03% CHEMBL3645194
Sofosbuvir NS5B_HCV1B Genome polyprotein -7.84 -8.35 -7.78 28.75% CHEMBL4111989
Brequinar NS5B_HCV2A Genome polyprotein -10.67 -10.38 N/A 19.57% CHEMBL3127326
Niclosamide NS5B_HCV2A Genome polyprotein -8.30 -8.66 N/A 34.84% CHEMBL3127326
Sofosbuvir NS5B_HCV2A Genome polyprotein -9.27 -9.02 N/A 16.89% CHEMBL4203791
Brequinar NS5_9FLAV Core protein -9.47 N/A N/A N/A N/A
Niclosamide NS5_9FLAV Core protein -7.69 N/A N/A N/A N/A
Sofosbuvir NS5_9FLAV Core protein -8.37 N/A N/A N/A N/A
Brequinar NS5_DEN3S Genome polyprotein -8.98 -8.55 N/A N/A N/A
Niclosamide NS5_DEN3S Genome polyprotein -6.78 -7.27 N/A N/A N/A
Sofosbuvir NS5_DEN3S Genome polyprotein -7.46 -8.27 N/A N/A N/A
Brequinar NS5_ZIKV Genome polyprotein -9.75 -6.32 N/A N/A N/A
Niclosamide NS5_ZIKV Genome polyprotein -7.85 -5.57 N/A N/A N/A
Sofosbuvir NS5_ZIKV Genome polyprotein -8.34 -5.96 N/A N/A N/A
Brequinar NS5_ZIKVF Genome polyprotein -8.89 N/A N/A N/A N/A
Niclosamide NS5_ZIKVF Genome polyprotein -7.96 N/A N/A N/A N/A
Sofosbuvir NS5_ZIKVF Genome polyprotein -8.28 N/A N/A N/A N/A
Brequinar NS6_9CALI NTPase -5.90 -6.48 -7.77 N/A N/A
Niclosamide NS6_9CALI NTPase -4.99 -6.12 -5.97 N/A N/A
Sofosbuvir NS6_9CALI NTPase -5.35 -5.92 -6.46 N/A N/A
Brequinar NSP15_SARS Replicase polyprotein 1ab -7.71 N/A N/A 24.36% CHEMBL221366
Niclosamide NSP15_SARS Replicase polyprotein 1ab -6.77 N/A N/A 18.97% CHEMBL3105073
Sofosbuvir NSP15_SARS Replicase polyprotein 1ab -6.92 N/A N/A 18.41% CHEMBL2441745
Brequinar NSP15_SARS2 Replicase polyprotein 1ab -8.05 N/A N/A N/A N/A
Niclosamide NSP15_SARS2 Replicase polyprotein 1ab -7.56 N/A N/A N/A N/A
Sofosbuvir NSP15_SARS2 Replicase polyprotein 1ab -6.91 N/A N/A N/A N/A
Brequinar NSP1_INFB Non-structural protein 1 -7.81 -7.20 N/A N/A N/A
Niclosamide NSP1_INFB Non-structural protein 1 -6.10 -5.86 N/A N/A N/A
Sofosbuvir NSP1_INFB Non-structural protein 1 -6.15 -6.48 N/A N/A N/A
Brequinar NSP1_SARS Replicase polyprotein 1ab -6.72 N/A N/A 24.36% CHEMBL221366
Niclosamide NSP1_SARS Replicase polyprotein 1ab -5.89 N/A N/A 18.97% CHEMBL3105073
Sofosbuvir NSP1_SARS Replicase polyprotein 1ab -6.01 N/A N/A 18.41% CHEMBL2441745
Brequinar NSP3_HCoV-229E Replicase polyprotein 1a -9.66 N/A N/A N/A N/A
Niclosamide NSP3_HCoV-229E Replicase polyprotein 1a -8.68 N/A N/A N/A N/A
Sofosbuvir NSP3_HCoV-229E Replicase polyprotein 1a -8.84 N/A N/A N/A N/A
Brequinar NSP3_IBV Replicase polyprotein 1a -9.66 N/A N/A N/A N/A
Niclosamide NSP3_IBV Replicase polyprotein 1a -9.04 N/A N/A N/A N/A
Sofosbuvir NSP3_IBV Replicase polyprotein 1a -8.42 N/A N/A N/A N/A
Brequinar NSP3_MHV Replicase polyprotein 1ab -7.88 N/A N/A N/A N/A
Niclosamide NSP3_MHV Replicase polyprotein 1ab -6.95 N/A N/A N/A N/A
Sofosbuvir NSP3_MHV Replicase polyprotein 1ab -6.64 N/A N/A N/A N/A
Brequinar NSP3_SARS2 Replicase polyprotein 1ab -8.23 N/A N/A N/A N/A
Niclosamide NSP3_SARS2 Replicase polyprotein 1ab -6.85 N/A N/A N/A N/A
Sofosbuvir NSP3_SARS2 Replicase polyprotein 1ab -6.90 N/A N/A N/A N/A
Brequinar NSP9_HCoV-229E Replicase polyprotein 1ab -7.36 -6.83 N/A N/A N/A
Niclosamide NSP9_HCoV-229E Replicase polyprotein 1ab -7.04 -5.83 N/A N/A N/A
Sofosbuvir NSP9_HCoV-229E Replicase polyprotein 1ab -6.32 -7.11 N/A N/A N/A
Brequinar PA_A-H17N10 Polymerase acidic protein -8.29 N/A N/A N/A N/A
Niclosamide PA_A-H17N10 Polymerase acidic protein -7.05 N/A N/A N/A N/A
Sofosbuvir PA_A-H17N10 Polymerase acidic protein -8.22 N/A N/A N/A N/A
Brequinar PA_A-H1N1 Polymerase acidic protein -8.08 -8.83 -9.56 N/A N/A
Niclosamide PA_A-H1N1 Polymerase acidic protein -7.42 -8.22 -7.45 N/A N/A
Sofosbuvir PA_A-H1N1 Polymerase acidic protein -8.52 -8.42 -9.13 N/A N/A
Brequinar PA_A-H5N1 Polymerase acidic protein -8.81 -8.52 -9.07 N/A N/A
Niclosamide PA_A-H5N1 Polymerase acidic protein -7.88 -7.50 -7.72 N/A N/A
Sofosbuvir PA_A-H5N1 Polymerase acidic protein -8.31 -8.05 -8.96 N/A N/A
Brequinar PA_INFA Polymerase acidic protein -10.06 -8.48 -8.26 43.75% CHEMBL4440338
Niclosamide PA_INFA Polymerase acidic protein -8.60 -7.45 -7.41 38.97% CHEMBL2070214
Sofosbuvir PA_INFA Polymerase acidic protein -8.57 -9.15 -8.68 24.61% CHEMBL3944613
Brequinar PA_INFB Polymerase acidic protein -9.02 N/A N/A N/A N/A
Niclosamide PA_INFB Polymerase acidic protein -7.63 N/A N/A N/A N/A
Sofosbuvir PA_INFB Polymerase acidic protein -7.98 N/A N/A N/A N/A
Brequinar PB2_A-H3N2 Polymerase basic protein 2 -8.35 -9.08 N/A N/A N/A
Niclosamide PB2_A-H3N2 Polymerase basic protein 2 -7.88 -8.02 N/A N/A N/A
Sofosbuvir PB2_A-H3N2 Polymerase basic protein 2 -7.33 -7.84 N/A N/A N/A
Brequinar PB2_A-H5N1 Polymerase basic protein 2 -8.27 -8.45 -9.59 N/A N/A
Niclosamide PB2_A-H5N1 Polymerase basic protein 2 -7.39 -7.42 -8.32 N/A N/A
Sofosbuvir PB2_A-H5N1 Polymerase basic protein 2 -7.16 -6.86 -7.64 N/A N/A
Brequinar PB2_INFB Polymerase basic protein 2 -8.71 N/A N/A N/A N/A
Niclosamide PB2_INFB Polymerase basic protein 2 -8.08 N/A N/A N/A N/A
Sofosbuvir PB2_INFB Polymerase basic protein 2 -7.71 N/A N/A N/A N/A
Brequinar PB3_A-H3N2 Polymerase basic protein 2 -8.88 N/A N/A N/A N/A
Niclosamide PB3_A-H3N2 Polymerase basic protein 2 -7.98 N/A N/A N/A N/A
Sofosbuvir PB3_A-H3N2 Polymerase basic protein 2 -7.40 N/A N/A N/A N/A
Brequinar PB4_A-H3N2 Polymerase basic protein 2 -8.33 N/A N/A N/A N/A
Niclosamide PB4_A-H3N2 Polymerase basic protein 2 -7.46 N/A N/A N/A N/A
Sofosbuvir PB4_A-H3N2 Polymerase basic protein 2 -7.50 N/A N/A N/A N/A
Brequinar PLP_SARS Replicase polyprotein 1a -10.39 -10.25 -9.94 33.97% CHEMBL225515
Niclosamide PLP_SARS Replicase polyprotein 1a -7.94 -8.81 -8.94 37.06% CHEMBL358279
Sofosbuvir PLP_SARS Replicase polyprotein 1a -9.21 -8.52 -9.19 19.13% CHEMBL212080
Brequinar PLP_SARS2 papain-like protease -7.15 N/A N/A N/A N/A
Niclosamide PLP_SARS2 papain-like protease -6.34 N/A N/A N/A N/A
Sofosbuvir PLP_SARS2 papain-like protease -6.88 N/A N/A N/A N/A
Brequinar PM_9VIRU RNA-directed RNA polymerase L -8.98 -8.68 N/A N/A N/A
Niclosamide PM_9VIRU RNA-directed RNA polymerase L -7.79 -7.12 N/A N/A N/A
Sofosbuvir PM_9VIRU RNA-directed RNA polymerase L -8.24 -7.60 N/A N/A N/A
Brequinar PR_FCoV Replicase polyprotein 1ab -7.22 N/A N/A 14.57% CHEMBL4214471
Niclosamide PR_FCoV Replicase polyprotein 1ab -7.43 N/A N/A 15.43% CHEMBL4214471
Sofosbuvir PR_FCoV Replicase polyprotein 1ab -7.39 N/A N/A 18.31% CHEMBL4214471
Brequinar PR_HCoV-229E Replicase polyprotein 1a -8.19 -6.97 N/A N/A N/A
Niclosamide PR_HCoV-229E Replicase polyprotein 1a -7.53 -6.88 N/A N/A N/A
Sofosbuvir PR_HCoV-229E Replicase polyprotein 1a -8.12 -7.82 N/A N/A N/A
Brequinar PR_HCoV-NL63 Replicase polyprotein 1a -4.87 -8.79 N/A N/A N/A
Niclosamide PR_HCoV-NL63 Replicase polyprotein 1a -4.49 -7.33 N/A N/A N/A
Sofosbuvir PR_HCoV-NL63 Replicase polyprotein 1a -5.00 -7.63 N/A N/A N/A
Brequinar PR_HIV1 Gag-Pol polyprotein -7.45 -7.26 -7.20 15.21% CHEMBL450294
Niclosamide PR_HIV1 Gag-Pol polyprotein -6.57 -7.25 -6.58 17.65% CHEMBL503401
Sofosbuvir PR_HIV1 Gag-Pol polyprotein -6.36 -6.70 -6.80 25.00% CHEMBL3645127
Brequinar PR_HIV2 Gag-Pol polyprotein -8.27 -7.26 N/A N/A N/A
Niclosamide PR_HIV2 Gag-Pol polyprotein -7.03 -6.10 N/A N/A N/A
Sofosbuvir PR_HIV2 Gag-Pol polyprotein -6.94 -6.83 N/A N/A N/A
Brequinar PR_HKU1 Replicase polyprotein 1a -7.17 N/A N/A N/A N/A
Niclosamide PR_HKU1 Replicase polyprotein 1a -7.75 N/A N/A N/A N/A
Sofosbuvir PR_HKU1 Replicase polyprotein 1a -6.82 N/A N/A N/A N/A
Brequinar PR_HKU4 Replicase polyprotein 1ab -7.79 -7.72 -7.70 N/A N/A
Niclosamide PR_HKU4 Replicase polyprotein 1ab -7.10 -7.41 -7.25 N/A N/A
Sofosbuvir PR_HKU4 Replicase polyprotein 1ab -7.64 -7.59 -7.49 N/A N/A
Brequinar PR_IBV Replicase polyprotein 1a -8.32 N/A N/A N/A N/A
Niclosamide PR_IBV Replicase polyprotein 1a -6.89 N/A N/A N/A N/A
Sofosbuvir PR_IBV Replicase polyprotein 1a -7.94 N/A N/A N/A N/A
Brequinar PR_MERs 3C-like proteinase -7.39 -7.81 N/A N/A N/A
Niclosamide PR_MERs 3C-like proteinase -7.80 -7.23 N/A N/A N/A
Sofosbuvir PR_MERs 3C-like proteinase -7.19 -8.00 N/A N/A N/A
Brequinar PR_PEDV 3C-like proteinase -7.66 N/A N/A N/A N/A
Niclosamide PR_PEDV 3C-like proteinase -7.47 N/A N/A N/A N/A
Sofosbuvir PR_PEDV 3C-like proteinase -7.65 N/A N/A N/A N/A
Brequinar PR_SARS Replicase polyprotein 1ab -8.39 -8.83 -8.54 24.36% CHEMBL221366
Niclosamide PR_SARS Replicase polyprotein 1ab -7.56 -7.11 -6.97 18.97% CHEMBL3105073
Sofosbuvir PR_SARS Replicase polyprotein 1ab -7.84 -7.77 -7.07 18.41% CHEMBL2441745
Brequinar PR_SARS2 3C-like protease -7.74 N/A N/A N/A N/A
Niclosamide PR_SARS2 3C-like protease -7.45 N/A N/A N/A N/A
Sofosbuvir PR_SARS2 3C-like protease -7.93 N/A N/A N/A N/A
Brequinar PR_TGEV Replicase polyprotein 1a -7.44 N/A N/A N/A N/A
Niclosamide PR_TGEV Replicase polyprotein 1a -6.76 N/A N/A N/A N/A
Sofosbuvir PR_TGEV Replicase polyprotein 1a -7.27 N/A N/A N/A N/A
Brequinar P_9CALI Norovirus P domain protein -9.83 N/A N/A N/A N/A
Niclosamide P_9CALI Norovirus P domain protein -7.97 N/A N/A N/A N/A
Sofosbuvir P_9CALI Norovirus P domain protein -8.04 N/A N/A N/A N/A
Brequinar P_NVN68 Capsid protein VP1 -6.62 N/A N/A N/A N/A
Niclosamide P_NVN68 Capsid protein VP1 -5.55 N/A N/A N/A N/A
Sofosbuvir P_NVN68 Capsid protein VP1 -5.87 N/A N/A N/A N/A
Brequinar RDRP_SARS2 RNA-dependent RNA polymerase -6.73 N/A N/A 17.11% CHEMBL4065616
Niclosamide RDRP_SARS2 RNA-dependent RNA polymerase -6.09 N/A N/A 13.11% CHEMBL4065616
Sofosbuvir RDRP_SARS2 RNA-dependent RNA polymerase -6.56 N/A N/A 49.20% CHEMBL4065616
Brequinar RT_HIV1 Gag-Pol polyprotein -11.48 -10.79 -10.89 32.34% CHEMBL4288759
Niclosamide RT_HIV1 Gag-Pol polyprotein -8.41 -8.35 -8.61 26.67% CHEMBL4227382
Sofosbuvir RT_HIV1 Gag-Pol polyprotein -8.66 -9.37 -9.29 22.19% CHEMBL4108778
Brequinar SPIKE_HCoV-229E Spike glycoprotein -6.85 N/A N/A N/A N/A
Niclosamide SPIKE_HCoV-229E Spike glycoprotein -4.92 N/A N/A N/A N/A
Sofosbuvir SPIKE_HCoV-229E Spike glycoprotein -5.24 N/A N/A N/A N/A
Brequinar SPIKE_HCoV-NL63 Spike glycoprotein -7.14 N/A N/A N/A N/A
Niclosamide SPIKE_HCoV-NL63 Spike glycoprotein -5.81 N/A N/A N/A N/A
Sofosbuvir SPIKE_HCoV-NL63 Spike glycoprotein -5.85 N/A N/A N/A N/A
Brequinar SPIKE_HCoV-OC43 Spike glycoprotein -7.53 N/A N/A N/A N/A
Niclosamide SPIKE_HCoV-OC43 Spike glycoprotein -6.24 N/A N/A N/A N/A
Sofosbuvir SPIKE_HCoV-OC43 Spike glycoprotein -6.82 N/A N/A N/A N/A
Brequinar SPIKE_HKU4 Spike glycoprotein -7.68 N/A N/A N/A N/A
Niclosamide SPIKE_HKU4 Spike glycoprotein -7.70 N/A N/A N/A N/A
Sofosbuvir SPIKE_HKU4 Spike glycoprotein -7.16 N/A N/A N/A N/A
Brequinar SPIKE_IBV Spike glycoprotein -6.80 N/A N/A N/A N/A
Niclosamide SPIKE_IBV Spike glycoprotein -5.98 N/A N/A N/A N/A
Sofosbuvir SPIKE_IBV Spike glycoprotein -6.32 N/A N/A N/A N/A
Brequinar SPIKE_MERs Spike glycoprotein -8.22 -7.36 -6.74 N/A N/A
Niclosamide SPIKE_MERs Spike glycoprotein -7.11 -6.56 -5.53 N/A N/A
Sofosbuvir SPIKE_MERs Spike glycoprotein -6.79 -5.92 -5.96 N/A N/A
Brequinar SPIKE_MHV Spike glycoprotein -7.65 N/A N/A N/A N/A
Niclosamide SPIKE_MHV Spike glycoprotein -6.84 N/A N/A N/A N/A
Sofosbuvir SPIKE_MHV Spike glycoprotein -6.94 N/A N/A N/A N/A
Brequinar SPIKE_PDCoV Spike protein -7.01 N/A N/A N/A N/A
Niclosamide SPIKE_PDCoV Spike protein -6.43 N/A N/A N/A N/A
Sofosbuvir SPIKE_PDCoV Spike protein -6.96 N/A N/A N/A N/A
Brequinar SPIKE_SARS Spike glycoprotein -7.07 -7.45 N/A N/A N/A
Niclosamide SPIKE_SARS Spike glycoprotein -7.31 -6.69 N/A N/A N/A
Sofosbuvir SPIKE_SARS Spike glycoprotein -6.50 -6.73 N/A N/A N/A
Brequinar SPIKE_SARS2 Spike glycoprotein -7.30 -6.91 -6.77 N/A N/A
Niclosamide SPIKE_SARS2 Spike glycoprotein -6.03 -5.91 -6.18 N/A N/A
Sofosbuvir SPIKE_SARS2 Spike glycoprotein -6.09 -6.25 -6.27 N/A N/A
Brequinar VP1_9CALI Capsid protein -10.10 N/A N/A N/A N/A
Niclosamide VP1_9CALI Capsid protein -8.22 N/A N/A N/A N/A
Sofosbuvir VP1_9CALI Capsid protein -8.73 N/A N/A N/A N/A
Brequinar VP1_NVN68 Capsid protein VP1 -7.61 N/A N/A N/A N/A
Niclosamide VP1_NVN68 Capsid protein VP1 -5.29 N/A N/A N/A N/A
Sofosbuvir VP1_NVN68 Capsid protein VP1 -5.66 N/A N/A N/A N/A
Brequinar VP24_EBORE Membrane-associated protein VP24 -6.06 N/A N/A N/A N/A
Niclosamide VP24_EBORE Membrane-associated protein VP24 -5.80 N/A N/A N/A N/A
Sofosbuvir VP24_EBORE Membrane-associated protein VP24 -5.89 N/A N/A N/A N/A
Brequinar VP24_EBOSU Membrane-associated protein VP24 -6.23 N/A N/A N/A N/A
Niclosamide VP24_EBOSU Membrane-associated protein VP24 -5.25 N/A N/A N/A N/A
Sofosbuvir VP24_EBOSU Membrane-associated protein VP24 -5.42 N/A N/A N/A N/A
Brequinar VP24_EBOZM Membrane-associated protein VP24 -7.24 N/A N/A N/A N/A
Niclosamide VP24_EBOZM Membrane-associated protein VP24 -5.84 N/A N/A N/A N/A
Sofosbuvir VP24_EBOZM Membrane-associated protein VP24 -5.63 N/A N/A N/A N/A
Brequinar VP30_9MONO Minor nucleoprotein VP30 -7.29 N/A N/A N/A N/A
Niclosamide VP30_9MONO Minor nucleoprotein VP30 -6.30 N/A N/A N/A N/A
Sofosbuvir VP30_9MONO Minor nucleoprotein VP30 -6.24 N/A N/A N/A N/A
Brequinar VP30_EBOZ5 Transcriptional activator VP30 -7.63 N/A N/A N/A N/A
Niclosamide VP30_EBOZ5 Transcriptional activator VP30 -6.92 N/A N/A N/A N/A
Sofosbuvir VP30_EBOZ5 Transcriptional activator VP30 -6.45 N/A N/A N/A N/A
Brequinar VP30_EBOZM Transcriptional activator VP30 -8.84 N/A N/A N/A N/A
Niclosamide VP30_EBOZM Transcriptional activator VP30 -7.02 N/A N/A N/A N/A
Sofosbuvir VP30_EBOZM Transcriptional activator VP30 -7.03 N/A N/A N/A N/A
Brequinar VP35_EBORR Polymerase cofactor VP35 -6.85 N/A N/A N/A N/A
Niclosamide VP35_EBORR Polymerase cofactor VP35 -5.81 N/A N/A N/A N/A
Sofosbuvir VP35_EBORR Polymerase cofactor VP35 -6.36 N/A N/A N/A N/A
Brequinar VP35_EBOZM Polymerase cofactor VP35 -7.41 -6.85 -7.62 N/A N/A
Niclosamide VP35_EBOZM Polymerase cofactor VP35 -5.64 -6.24 -6.00 N/A N/A
Sofosbuvir VP35_EBOZM Polymerase cofactor VP35 -6.23 -6.72 -7.08 N/A N/A
Brequinar VP40_EBOZM Matrix protein VP40 -6.42 -6.33 N/A N/A N/A
Niclosamide VP40_EBOZM Matrix protein VP40 -5.57 -5.42 N/A N/A N/A
Sofosbuvir VP40_EBOZM Matrix protein VP40 -5.93 -5.98 N/A N/A N/A